Yuuki’s earliest memory is of a snowy night in winter, when she was attacked by a vampire and was saved by another, Kaname Kuran. Ten years later, Yuuki Cross, the adopted daughter of the headmaster of Cross Academy, has grown up and become a prefect for the school with two purposes: to protect the Day class students (humans) from the Night class students (vampires) and to protect the true identity of the Night class students from being discovered by the Day class students.
Her fellow guardian, Zero Kiryu, a childhood companion whose parents were killed by a pureblood vampire, is now determined to kill them all and refuses to trust them. Through a cruel twist of fate, Zero becomes a vampire himself, having been bitten by a pureblood vampire four years before, Shizuka Hiou. Kaname, Yuuki’s savior, leads the group of Night class, with the help of Takuma Ichijou (the vice president).